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A method of modulating the activity of a nucleic acid molecule

The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same.

Duke File (IDF) Number



  • Sullenger, Bruce
  • Oney, Sabah

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School of Medicine (SOM)