A mouse model of focal segmental glomerulosclerosis (FSGS)

A mouse model of focal segmental glomerulosclerosis (FSGS) was generated by expressing a constitutively active Gq alpha-subunit (GqQ>L) in glomerular podocytes in a doxycycline regulatable fashion and treating the Gq mice with the podocyte toxin puromycin aminonucleoside (PAN).

Duke File (IDF) Number

T-005078

Inventor(s)

  • Spurney, Robert
  • Buckley, Anne
  • Fields, Timothy
  • Rosenberg, Paul
  • Wang, Liming

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College

School of Medicine (SOM)