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A novel method for augmenting the effect SSRIs

A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enahancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse.

Duke File (IDF) Number



  • Krishnan, K. Ranga
  • Beaulieu, Martin
  • Caron, Marc G
  • Gainetdinov, Raul
  • Sotnikova, Tatiana
  • Zhang, Xiaodong

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School of Medicine (SOM)