A Novel target, mechanism and strategy for utilizing HDAC inhibitors in cancer therapy

Methods of inhibiting cancer cell growth using HDAC10 inhibitors are provided. Methods of treating cancer in a subject using HDAC10 inhibitors are also provided. In certain embodiments, at least one second inhibitor selected from an autophagy inhibitor, an AMPK inhibitor, and methyl pyruvate is also used in the methods. Dose packs comprising HDAC10 inhibitors and at least one second inhibitor are provided. Methods of identifying HDAC10 inhibitors are also provided.

Duke File (IDF) Number

T-003152

Inventor(s)

  • Yao, Tso-Pang
  • Cui, Kai
  • Kawaguchi, Yoshiharu
  • Lai, Chun-Hsiang
  • Sasajima, Hitoshi

Patents

    • Patent Number: 8,664,182
    • Title: METHODS OF INHIBITING CANCER CELL GROWTH WITH HDAC INHIBITORS AND METHODS OF SCREENING FOR HDAC10 INHIBITORS
    • Country: United States of America

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College

School of Medicine (SOM)