Activated caspase-3 reporter mouse

The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and hence progression towards apoptosis.

Duke File (IDF) Number

T-003933

Inventor(s)

  • Nicholls, Peter
  • Caron, Marc G
  • Johnson, George

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College

School of Medicine (SOM)