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Aptamers to VMF

Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific binding to a target. Aptamers which are selected or derivatives thereof may be used for those specific activities in biological systems. Any combination of deconvoluting a focused library (functional profiling), increasing frequencies of particular aptamers in a focused library (Laser SELEX), and decreasing frequencies of particular aptamers in a focused library (DeSELEX) may be performed prior to assaying biological activity.

Duke File (IDF) Number

T-002561

Inventor(s)

  • Sullenger, Bruce
  • Layzer, Juliana
  • Oney, Sabah
  • Que-Gewirth, Nanette

For more information please contact

College

School of Medicine (SOM)

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