Blood gas machine that measures nitric oxide

Value proposition

Nitric oxide is essential in maintaining microvascular function by regulating tissue oxygenation. Deregulated levels of blood nitric oxide are implicated in the pathogenesis of many diseases including sickle cell disease, pulmonary hypertension, and sepsis. Therefore, reliable and direct methods for monitoring the changes in nitric oxide in real-time are necessary.

Technology

The inventors have developed a diagnostic tool for measuring blood nitric oxide. Blood samples to be analyzed are irradiated with ultraviolet electromagnetic radiation to liberate nitric oxide gas from combined nitric oxide in a blood sample. The system is coupled to a detection system that measures the amount of the liberated nitric oxide gas which corresponds to the total amount of nitric oxide present.

Advantages

  • Can be incorporated into a standard blood gas machine to measure oxygen, carbon dioxide, and nitric oxide
  • High sensitivity for nitric oxide metabolites
  • Amenable for use in the laboratory- does not require sample preparation or contamination by blood samples
3D illustration of the flow of red blood cells

Duke File (IDF) Number

T-002702

Inventor(s)

  • Stamler, Jonathan
  • Angelo, Robert

Patents

    • Patent Number: 9,562,913
    • Title: METHOD FOR LIBERATING AND DETECTING NITRIC OXIDE FROM NITROSOTHIOLS AND IRON NITROSYLS IN BLOOD
    • Country: United States of America

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College

School of Medicine (SOM)