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C-nitroso Donors of Neutral Nitric Oxide

C-nitroso compound capable of releasing neutral nitric oxide is made stable by forming a Diels Alder adduct thereof which is functionalized at the Diels-Alder double bond to impart the stability. Treatment of the stabilized adduct with agent that removes functionalization and regenerates Diels Alder double bond triggers delivery of neutral nitric oxide via retro Diels-Alder reaction and hemolytic scission.

Duke File (IDF) Number

T-002733

Inventor(s)

  • Toone, Eric
  • Chakrapani, Harinath

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College

Trinity College of Arts & Sciences

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