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Novel factor VIIa chimeras for safer hemostasis

Novel factor VIIa chimeras for safer hemostasis

Unmet Need Chronic wounds impact 6.5 million patients in the US, leading to complications such as infections, hemorrhage, gangrene, and amputations. The resulting health burden costs the US healthcare system an estimated $25 billion annually…

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Surgical drain for fluid collection

Surgical drain for fluid collection

Unmet Need Surgical drains are an essential component of various surgical procedures including chest drainage, abdominal surgery, plastic surgery, and neurosurgery. Roughly 4.2 million of these surgeries performed annually in the US require at least…

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Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…

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A method of determining resistance of a blood cancer to PI3K inhibitors as well as treating blood cancers

A method of determining resistance of a blood cancer to PI3K inhibitors as well as treating blood cancers

Unmet Need Lymphomas are highly diverse and among the most common cancers in the US; approximately 1 in 50 Americans will be diagnosed with a lymphoma in their lifetime. Standard therapy for lymphomas generally includes…

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G protein-coupled receptor kinase 2 and beta arrestins as therapeutic targets and diagnostic tools for hemoglobinopathies

G protein-coupled receptor kinase 2 and beta arrestins as therapeutic targets and diagnostic tools for hemoglobinopathies

Value Proposition Sickle cell disease affects millions of people throughout the world. Patients with sickle cell disease often experience episodes of acute pain that are caused by vaso-occlusive crisis. It is the leading cause of…

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RNA aptamers for thrombi imaging

RNA aptamers for thrombi imaging

Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…

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Aptamers to Glycoprotein VI

Aptamers to Glycoprotein VI

Value Proposition Millions of Americans have received antiplatelet agents to prevent pathological blood clot formation (thrombosis). Platelets are the key prothrombotic element, forming aggregates that lead to blood clots. Antiplatelet therapies can counteract this process.…

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Controlling coagulation with aptamer combinations and aptamer-drug combinations and their antidotes

Controlling coagulation with aptamer combinations and aptamer-drug combinations and their antidotes

Value Proposition Millions of Americans have received anticoagulative agents to prevent pathological blood clot formation (thrombosis). For decades, warfarin and heparin have been the centerpiece of anticoagulative treatment. In the past decade, new anticoagulative agents…

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RNA Aptamers Targeting a coagulation Cascade Cofactor

RNA Aptamers Targeting a coagulation Cascade Cofactor

Value Proposition Thrombosis (blood clots within blood vessels) is a major underlying factor in many cardiovascular diseases and a major source for complications following hospital stays and surgeries. Venous thrombosis occurs in approximately 1 per…

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MEK inhibitors as therapeutic agents and diagnostic tools for hemoglobinopathies, including thalassemia

MEK inhibitors as therapeutic agents and diagnostic tools for hemoglobinopathies, including thalassemia

Value Proposition Patients with sickle cell disease experience acute vaso-occlusive “crises”, which lead to significant pain, multiple organ damage, and eventually organ failure. Such crises are caused largely by their abnormal sickle red blood cells,…

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Aptamers to VMF

Aptamers to VMF

Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific…

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