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MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients
Unmet Need Sepsis is a life-threatening emergency characterized by an overactive and improper inflammatory response by the body to an infection or injury leading to tissue damage, organ failure and death if not treated promptly.…
LpxH targeting antibiotics for Gram-negative bacteria
Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…
HIV treatment and prevention using broadly neutralizing antibodies
Unmet Need For over 40 years, the human immunodeficiency virus (HIV) pandemic has affected the quality of life and decreased the life expectancy for millions of people with approximately 1.5 million new cases each year.…
Smart microscope for diagnosing disease
Value Proposition Since its invention, the microscope has been optimized for interpretation by a human observer. Recently, however, deep learning algorithms have been developed for automated image analysis in a variety of important contexts, such…
CRISPR-based antiviral treatment of coronavirus infections
Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…
Wearable device for early detection of influenza and common cold
Unmet Need Approximately 10% of the US population is infected with influenza each year resulting in 3 to 5 million severe cases and up to 500,000 deaths. Early detection of influenza-like illness can limit the…
Novel diagnostic method for aspergillus Infection
Unmet Need Invasive aspergillosis (IA) is a major cause of critical illness in immunocompromised patients. IA is caused by Aspergillus, a type of fungal mold, and it usually affects the host’s pulmonary structure. While most…
Small molecules that target RNA structures within the CoV genome
Unmet Need SARS-CoV-2 is the etiological agent of the COVID-19 respiratory disease, the largest scale respiratory virus pandemic the world has witnessed since the 1918 Spanish flu and that has claimed more than 1.4 million…
Platform for generating a seasonal vaccine for both influenza and coronaviruses
Unmet Need Similar to the flu vaccine, the need for seasonal post-immunization boosting to offer protection following COVID-19 vaccines remains possible. However, more than 8 percent of people who received a first dose of Pfizer…
A method for treating pain and inflammation using GPR37 agonists
Unmet Need Uncontrolled inflammation is a prominent component of many common diseases and is the root cause of chronic pain. When inflammation persists, the inflammatory factors are never completely cleared from the system, leading to…
Synthetic peptide adjuvants for mucosally-administered vaccines
Provided herein are peptides that have activity as mast cell activating proteins (MCAP), as well as compositions, adjuvant compositions, vaccines, and pharmaceutical formulations that include the peptides. Also provided are methods of using the peptides,…
Enhancing immune responses in a variety of applications with a lymph node targeting biodegradable nanoparticle
Unmet Need While vaccines have resulted in plummeting mortality rates in the human population over the last century, significant challenges remain for which current vaccine formulations fall short. For example, current influenza vaccines are unable…