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Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma

Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma

Unmet Need Chimeric Antigen Receptor (CAR) T-cell therapy, a form of immunotherapy, has proven highly effective against blood cancers such as leukemias and lymphomas. This therapy uses T-cells that are genetically engineering ex vivo to…

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Treating the brain from the gut

Treating the brain from the gut

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A smartphone-based detector for mobile health applications

A smartphone-based detector for mobile health applications

Unmet Need It is estimated that there are over 6 billion smartphone users worldwide, which translates to almost 83% of the world’s population. Due to their widespread use, smartphones present a golden opportunity to redefine…

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A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts

A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts

Unmet Need Cis-regulatory elements (cREs) of the genome are non-coding regions that play essential roles in regulating gene expression in development and disease. Importantly, these regions are characterized by the presence of “open” chromatin and…

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A tool to facilitate high affinity binding between beta-Arrestin and GPCR

A tool to facilitate high affinity binding between beta-Arrestin and GPCR

Unmet Need Beta-arrestins are a highly conserved family of cytosolic adaptor proteins that contribute to a multitude of physiological functions through a canonical interaction with various G protein-coupled receptors (GPCRs). Through agonist binding to GPCRs,…

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A method to optimize neural activity blocking therapies

A method to optimize neural activity blocking therapies

Unmet Need The use of kilohertz frequency (KHF) as neuromodulatory therapies that block unwanted neural activity have been applied to treat chronic pain, phantom limb pain, obesity, and other applications. However, the high energy demands…

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Flexible needle for targeted delivery of chronic pain treatment

Flexible needle for targeted delivery of chronic pain treatment

Unmet Need For patients suffering from chronic pain associated with degenerative changes, inflammation, neuropathy or cancer, the ability to carry out daily life and work activities is a challenge. Current treatment methods are limited and…

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A process to selectively access allylic diamines that can aid in identifying new drug compounds

A process to selectively access allylic diamines that can aid in identifying new drug compounds

Unmet Need When developing new drugs, researchers often rely on naturally occurring compounds to learn what design features illicit a biological response that can be tailored for treating a given disease or ailment. However, reproducing…

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Pallialytics, a machine learning model to determine palliative-care eligible patients

Pallialytics, a machine learning model to determine palliative-care eligible patients

Unmet Need Palliative care is specialized medical care that is focused on providing seriously ill patients with relief from symptoms, pain and stress. Palliative care can be provided at any time during an illness with…

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Memory-efficient deep learning algorithms for computed tomography image reconstruction

Memory-efficient deep learning algorithms for computed tomography image reconstruction

Unmet Need Using high resolution images such as computed tomography (CT) has become a popular tool to guide medical interventions from radiotherapy to dental implantation. The market for CT services is expected to grow from…

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Gene therapy and small molecule treatment of chronic pain without addiction

Gene therapy and small molecule treatment of chronic pain without addiction

Unmet Need Chronic pain is an escalating issue worldwide – in the U.S., an estimated one of five adults are affected. Chronic pain is difficult to treat, often requiring powerful opioids to provide relief. These…

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CRISPR-based antiviral treatment of coronavirus infections

CRISPR-based antiviral treatment of coronavirus infections

Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…

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