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Connecting cardiac and respiratory 3DCT imaging for 5DCT heart motion management
Unmet Need Ventricular tachycardia (VT) is a primary condition of heart disease noted as an irregularity of heart rhythm due to improper electrical signaling in the ventricles that causes an abnormally high heart rate. VT…
Cell and animal models of pulmonary fibrosis
Unmet Need Pulmonary fibrosis is an irreversible and progressive disease characterized by the buildup of fibrotic material in the lungs, reducing lung function. There are over 200 different types of pulmonary fibrosis resulting from numerous…
A device for clinical wet-to-wet connections that alleviates healthcare provider anxiety and enhances patient quality of care
Unmet Need Extracorporeal membrane oxygenation (ECMO) is a rapidly growing method of providing life-saving support to a patient suffering from heart or lung failure. Between 2010 and 2021 ECMO runs in the United States grew…
Dynamic MRI of lungs using perfluorinated gas mixtures
Unmet Need Chronic obstructive pulmonary disease (COPD) is the 3d leading cause of death in the US. It has consistently increased in frequency over the past 4 decades, currently including 15-20 million diagnosed cases. COPD…
Software to determine lung function based on 19F MRI lung images
Duke inventors have developed a software to determine lung function based on 19F MRI lung images. This technology, called Washout, calculates quantitative functional values for anatomic regions of the lung by fitting a model to…
Intubation tent to protect healthcare workers from infected patients
Value Proposition Under the current COVID crisis, health care workers need protection against respiratory infections transmitted by patients undergoing treatment. Patients undergoing intubation for surgery or prior to being placed on a ventilator can expose…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Strengthening a patient’s immune functions to prevent infectious diseases without developing antibiotic resistance
Unmet Need Despite the development of numerous antibiotics over the years, the arms race between humans and emergent antibiotic-resistant microbes remains. More than 2.8 million antibiotic-resistant infections and 35,000 deaths occur in the U.S. each…
Molecular diagnostic test for acute respiratory viral infections
Unmet Need Acute respiratory viral (ARV) infections are among the most common reasons for patient visits in primary and acute care settings. ARV can be caused by many viruses including human rhinovirus (HRV), respiratory syncytial…
Isolated organ viral, theraputic or cell therapy delivery
Value proposition Cardiovascular diseases (CVD) remain the leading cause of death worldwide. The number of CVD patients with heart failure (HF) in the US is approaching 6.5 million adults and is estimated to increase by…
Targeting hyaluronan, CD44 and lung fibroblast invasion to block fibrogenesis
Value Proposition Idiopathic pulmonary fibrosis (IPF) is the most common type of pulmonary fibrosis. Scarring causes stiffness in the lungs and makes it difficult to breathe. Currently, more than 80,000 adults in the United States…