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Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Aptamer anticoagulant therapy to reduce complications of ECMO treatment

Unmet Need Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment for critically ill patients with low oxygen levels. During ECMO, the patient’s blood flows through an external oxygenation device. This requires co-treatment with an anticoagulant…

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CRISPR-based antiviral treatment of coronavirus infections

CRISPR-based antiviral treatment of coronavirus infections

Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…

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Small molecules that target RNA structures within the CoV genome

Small molecules that target RNA structures within the CoV genome

Unmet Need SARS-CoV-2 is the etiological agent of the COVID-19 respiratory disease, the largest scale respiratory virus pandemic the world has witnessed since the 1918 Spanish flu and that has claimed more than 1.4 million…

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Fluorescence-based high-throughput assay for identifying antivirals to control COVID-19 pandemic

Fluorescence-based high-throughput assay for identifying antivirals to control COVID-19 pandemic

Unmet Need Current efforts to control COVID-19 are largely focused on behavioral modifications such as social distancing and the use of masks. These approaches attempt to slow the spread of the virus, but meaningful control…

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Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury

Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury

Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…

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