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An induced pluripotent stem cell model of Duchenne muscular dystrophy

An induced pluripotent stem cell model of Duchenne muscular dystrophy

Unmet Need Duchenne muscular dystrophy (DMD) is a rare genetic disease that causes the skeletal and heart muscles to weaken. Due to a mutation in dystrophin, an important protein involved in muscle structure, individuals with…

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Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…

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Novel epigenome editors for multiplexed gene regulation

Novel epigenome editors for multiplexed gene regulation

Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…

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Suppression of neuropathic pain by intrathecal delivery of bone marrow stem cells

Suppression of neuropathic pain by intrathecal delivery of bone marrow stem cells

Value proposition Neuropathic pain is a chronic, often debilitating condition caused by damage or injury to the nerves. Neuropathic pain is a common condition that result from various conditions trauma, viral infections, cancer, neurological conditions…

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Stem cell-derived factors for treating pathologic conditions

Stem cell-derived factors for treating pathologic conditions

1.3 million Americans experience a heart attack (acute myocardial infarction or AMI) each year. A significant percentage of these patients die from restricted blood flow to the heart (ischemia) and significant loss of cardiac function.…

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