Development of novel therapeutics to treat Non-Alcoholic Steatohepatitis (NASH)

Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are disclosed. The methods and compositions relate to inhibition of caspase-2.

Duke File (IDF) Number



  • Machado, Mariana
  • Diehl, Anna Mae
  • Kornbluth, Sally
  • Lindblom, Kelly
  • Michelotti, Gregory
  • Seagar-Johnson, Erika

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School of Medicine (SOM)