DNA detection probe and system for cancer diagnosis
Cancer is initially diagnosed after a positive screening test that leads to further investigation. Often these investigations require a multitude of blood, urine, and/or imaging studies to diagnose and fully characterize the disease. As with any diagnostic test, there exists a chance for erroneous results leading to unnecessary procedures. Furthermore, these tests all require significant time and money. A highly sensitive, cheap, rapid and mobile device that could be used as a point-of-care assay would mitigate much of the cost and anxiety surrounding cancer diagnosis and treatment planning.
The inventors have conceived of a noninvasive test using a sensitive, cheap and mobile device that would aid in cancer diagnosis and treatment planning. The invention comprises a novel method to accurately and rapidly detect mutated cellfree DNA (cfDNA) in bodily fluids, such as plasma and urine. The device would fluorescently detect tumor DNA without the need for amplification. For analysis, the inventors are also developing a miniature fluorescence DNA microarray detector without the need for filters and lenses. Another aspect of the invention detects DNA in a sample with multi wall carbon nanotubes achieved by using electrochemical impedance spectroscopy and cyclic voltammetry.
- Technology will enable much more rapid analysis than is currently possible by eliminating the need for complex sample preparation and signal amplification.
- Compact, miniaturized fluorescent detector eliminating the need for filters and lenses.
- Low price of device and measurement substrates will allow widespread and frequent use.
Duke File (IDF) Number
- Kirley, Matthew
- Fantony, Joesph
- Glass, Jeffrey
- Inman, Brant
- Ngaboyamahina, Edgard
- Parker, Charles
For more information please contact
- Baines, Bryan
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