Drd1 a-tdTomato BAC transgenic mouse

Fluorescent transgene (tdTomato) identifies cells with expression of tbe type I dopamine receptor in living and fixed preparations and may be used to distinguish unique features of cells expressing the type I dopamine receptor. In the striatum, these cells project to the direct pathway and as such are further useful for study of tbe basal ganglia circuitry. Because prior transgenic lines have relied exclusively upon tbe EGFP fluorophore. this transgenic mouse line makes possihle for the first time simultaneous visualization of thc Drdla-expressing cells with other EGFP transgenics, such as those in the indirect pathway of the basal ganglia.

Duke File (IDF) Number

T-003015

Inventor(s)

  • Calakos, Nicole

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College

School of Medicine (SOM)