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Functional single nucleotide polymorphism in brain-specific tryptophan hydroxylase (Tph2) as a tool for diagnosis and treatment of neuropsychiatric disorders.

A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.

Duke File (IDF) Number

2361

Inventor(s)

  • Caron, Marc
  • Beaulieu, Martin
  • Burch, Lauranell
  • Gainetdinov, Raul
  • Krishnan, Ranga
  • Schwartz, David
  • Sotnikova, Tatiana
  • Williams, Redford
  • Zhang, Xiaodong

For more information please contact

College

Duke University School of Medicine

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