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Interaction of covalently modified beta arrestins with stimulated G protein coupled receptors

The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.

Duke File (IDF) Number



  • Lefkowitz, Robert
  • Shenoy, Sudha

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School of Medicine (SOM)

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