Mouse model of cholinergic dysfunction to evaluate cognitive enhancers for Alzheimer’s disease treatment
Acetylcholine (ACh) plays a crucial role in controlling processes in the peripheral and central nervous system. Deficits in ACh neurotransmission is associated with memory loss and the performance of daily tasks, and have been described in several human disorders, including Alzheimer’s Disease and senile and multi-infarct dementia. Release of acetylcholine from nerve endings depends on the activity of a vesicular acetylcholine transporter (VAT). We have developed a mouse model in which VAT expression is decreased. This mouse model can be used to study cognitive disorders and can be used to screen compounds that would be effective in treating cognitive dysfunction. Patent protection is pending on this technology.
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