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Novel antimicrobial compounds for treating Gram-negative infections

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

Duke File (IDF) Number



  • Zhou, Pei
  • Chen, Xin
  • Lee, Chuljin
  • Liang, Xiaofei
  • Raetz, Christian
  • Toone, Eric

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School of Medicine (SOM)