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Novel Cardioprotective Agent for Global Myocardial Ischemia/Reperfusion Injury Exacerbated by Acute Hyperglycemia: Annexin-1 Short Peptide and PPARa Agaonist (ANX1+Wy) Combination Therapy

Value Proposition
Heart disease is the leading cause of death in industrialized nations across the world, with treatments often requiring “open-heart” surgery such as coronary artery bypass graft (CABG) or even transplantation. Although cardiac surgery is relatively common, it carries a high risk of complications stemming from ischemia-reperfusion injury. Two of the most common complications – perioperative myocardial injury / infarction (PMI) and acute kidney injury (AKI) – remain a major concern for patients undergoing cardiac surgery with current prophylaxis and treatment options unsatisfactory and only focused on managing the symptoms. This technology is intended to be administered perioperatively to a cardiac surgery patient to reduce risk of PMI and AKI.

Technology
This technology is a novel short peptide that with anti-inflammatory activity intended to be administered to patients before, during, and/or after cardiac surgery. When used in animal models of cardiac surgery, this technology significantly reduces biomarkers of myocardial injury including cardiac troponin (cTn1), heart-type fatty acid binding protein (HFABP), cardiac myeloperoxidase (MPO), and caspase-3. Importantly, this technology is similarly effective in reducing biomarkers of cardiac injury associated with intraoperative hyperglycemia. In models of AKI, this technology significantly reduces levels of the renal biomarker glutathione S transferase-mu (GST-mu), inflammatory cytokines, and renal tubular cell apoptosis.

Advantages
Current prophylaxis for PMI and AKI involve close monitoring of cardiac and renal physiology, with the administration of beta-blockers, statins, or other common cardiovascular drugs to keep cardiovascular physiology within defined parameters. Recent meta-analyses suggest that these interventions are largely ineffective and, in some cases, may even be harmful. This technology provides a novel means to prevent complications of cardiac surgery by controlling the inflammatory response, without requiring the use of glucocorticoids and their associated toxicity and side-effects.

Duke File (IDF) Number

T-003257

Inventor(s)

  • Zhang, Zhiquan
  • Ma, Qing
  • Podgoreanu, Mihai

For more information please contact

College

School of Medicine (SOM)

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