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Novel compound for inhibiting pain and inflammation in skin disorders

Value Proposition

Inflammation and pain are critical aspects of many dermatological disorders, with inflammation often driving disease progression while pain is a chronic and debilitating symptom of underlying disease processes. This technology provides a novel compound for alleviating both pain and inflammation in the skin by inhibiting a novel pathway critical for pain sensation and initiation of inflammation in keratinocytes. These novel inhibitors could be formulated as a therapy for topical application in a range of skin disorders including sunburn, autoimmune disorders, cancer, itch, skin allergy and others.

Technology

This technology comprises novel organic molecules which are demonstrated to inhibit the activity of the non-selective cation channel TRPV4. Using a mouse model of skin-specific TRPV4 deletion, the inventors demonstrated that the expression of TRPV4 in skin was important for both inflammation and pain elicited by UVB exposure in a mouse model of sunburn. Furthermore, topical application of a novel TRPV4 inhibitor recapitulated the decreased inflammation and pain threshold observed upon TRPV4 deletion. These findings suggest that TRPV4 inhibition may be useful as a novel therapy for skin disorders in humans.

Advantages

  • Ability to treat both pain and inflammation with a single compound instead of separate drugs
  • Simplify treatment for patients
  • Not disease-specific – many potential applications

Duke File (IDF) Number

T-003906

Inventor(s)

  • Liedtke, Wolfgang
  • Guilak, Farshid
  • Mook, Robert

Patents

    • Patent Number: 9,290,489
    • Title: ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH
    • Country: United States of America
    • Patent Number: 9,701,675
    • Title: ACTIVATON OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH
    • Country: United States of America

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College

School of Medicine (SOM)

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