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Novel hypoxia induced changes in alternative mRNA isoforms associated with clinical prognosis in solid tumorsx`

This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mRNA isoforms or downstream expression products thereof and comparing the relative expression level to relative historical or cohort expression levels of the same pair of mRNA isoforms. The result of the comparison can lead to a more accurate prognosis for the subject.

Duke File (IDF) Number



  • Robinson, Timothy
  • Dewhirst, Mark

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School of Medicine (SOM)