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Novel Mediators of Impaired Glucose-stimulated Insulin Secrection in Diabetes

The present invention provides methods for treating lipid-related diseases and disorders, e.g., hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, cardiovascular disease, obesity, and type II diabetes, and for modulating lipid biosynthesis, lipid transport, plasma triglyceride levels and/or plasma cholesterol levels, by modulating the expression or activity of PGC-1β. Methods for identifying compounds which are capable of treating or preventing a lipid-related disease or disorder are also described.

Duke File (IDF) Number



  • Newgard, Christopher
  • Lin, Jiandie
  • Spiegelman, Bruce
  • Yang, Ruojing

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School of Medicine (SOM)