Novel sour taste receptors

Novel Sour Taste Receptor. Technology: Duke University is seeking a company interested in commercializing the discovery of novel sour taste receptors in mammals. This exciting finding could dramatically affect the area of taste research. Extensive research is available on both the function and localization of these novel receptors. These receptors are selectively and abundantly expressed in taste tissues and localize specifically at the taste pore area in the taste buds on the tongue. Sour taste chemicals specifically activate these receptors, while other taste chemicals, such as salty, sweet, bitter and umami compounds, have no effects on these receptors. Applications: Use of cloned sour taste receptors enables cell-based assays to identify new sour taste blockers and enhancers without using humans or animals. Sour taste blockers could dramatically improve the taste of fruit, wine and other food and beverages. Advantages: o Improves efficiency and accuracy, and lowers costs in screening and research o Robust and conclusive data surrounding the invention

Duke File (IDF) Number



  • Matsunami, Hiroaki "Hiro"
  • Ishimaru, Yoshiro
  • Matsunami, Momoka

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School of Medicine (SOM)