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Self-gated interleaved radial MRI for motion detection of abdominothoracic tumors

Value Proposition

The accuracy and precision of several therapeutic interventions are often challenged by respiratory motion. Currently, 4D Computed Tomography (CT) is used in imaging organ and tumor respiratory motion. The mechanical design of CT scanners limits the sampling pattern and often leads to resampling artifacts. This modality also provides poor soft tissue contrast. In this context, the main advantage of magnetic resonance imaging (MRI) is the simplicity with which the sampling function can be designed and the wide range of inherent MR contrast mechanisms. However, MRI can impose strict timing requirements when imaging tissue, requiring prolonged acquisitions and/or numerous MR scans to generate an adequate image of tissue.


Inventors at Duke have developed a sampling strategy and a reconstruction method for a family of 4D-MRI pulse sequences to measure respiration-induced motion. MRI, in contrast to CT, allows the sampling function to be modified and adapted easily. The proposed strategy can also monitor breathing signal without any external tracking device, using the DC component in the sampling strategy. This method can measure respiratory motion at reduced acquisition times without compromising spatial resolution and coverage. Conversely, for a given span of time, it provides the highest resolution and coverage.


  • Measures Respiratory motion faster than any other 4D MRI modality without compromising spatial resolution and coverage
  • For a given span of time, provides better spatial resolution and coverage than any other 4D MRI modality

Duke File (IDF) Number



  • Subashi, Ergys
  • Cai, Jing


    • Patent Number: 15/600,041
    • Country: United States of America

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School of Medicine (SOM)

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