Back to available technologies

Vaccination against mutant ESR1 to prevent the development of endocrine resistance

Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding an ESRI polypeptide or a truncation, deletion or substitution mutant thereof. Methods of using the vaccine including the polynucleotide encoding the ESRl polypeptide to treat a cancer or precancer are also provided.

Duke File (IDF) Number



  • Lyerly, Herbert "Kim"
  • Hardman, Zach
  • Osada, Takuya

For more information please contact


School of Medicine (SOM)

Interested in this Technology?

Submit your interest below.