A method for treating pain and inflammation using GPR37 agonists

Value proposition

Uncontrolled inflammation is a prominent component of many common diseases and is the root cause of chronic pain. When inflammation persists, the inflammatory factors are never completely cleared from the system, leading to chronic pain. Treatments with anti-inflammatory drugs often prove ineffective, whereas opiates carry a risk of tolerance and addiction, especially with long-term use. The mechanisms that regulate resolution of inflammation and pain are not well understood. Research has revealed that the resolution of inflammation is an active process involving the production of specialized pro-resolution factors. These endogenous lipid mediators act on their respective G-protein-coupled receptors in immune cells to suppress pain. Thus, insights into mechanisms that can harness pro-resolution factors could lead to the development of more effective analgesics.

Technology

Researchers at Duke have discovered a method for treating pain and inflammation using a composition including a GPR37 agonist. They have discovered that GPR37, a G-protein coupled receptor expressed by macrophages, plays a central role in the resolution of inflammatory pain. GPR37 is a receptor for a pro-resolution factor, neuroprotectin D1. It triggers macrophage phagocytosis, shifts cytokine release toward an anti-inflammatory profile, and thereby helps to reverse inflammatory pain. This invention has been demonstrated in mouse models.

Other applications

This invention has the potential to treat other inflammation-related disorders, including infection, malaria, and sepsis.

Advantages

  • A novel therapeutic method that promotes the resolution of inflammation
  • Should have less side effects than anti-inflammatory drugs
  • Could have wide ranging applications including treating inflammation, inflammatory pain, viral and bacterial infection, malaria, and sepsis
GPR37's role in inflammation pathway

Duke File (IDF) Number

T-006341

Inventor(s)

  • Ji, Ru-Rong
  • Bang, Sangsu
  • Xu, Zhen-Zhong

Patents

    • Patent Number: PCT/US2019/035432
    • Title: COMPOSITIONS AND METHODS FOR TREATING PAIN, INFLAMMATION, INFECTION, MALARIA, AND SEPSIS
    • Country: United States of America

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College

School of Medicine (SOM)