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Chemical modulators of Immune Checkpoints and Therapeutic Use

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject

Duke File (IDF) Number



  • Chen, Wei
  • Guo, Hongtao
  • Hobeika, Amy
  • Lyerly, Herbert "Kim"
  • Mook, Robert "Bob"
  • Ren, Xiu-Rong
  • Wang, Jiangbo

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School of Medicine (SOM)

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