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Targeting hyaluronan, CD44 and lung fibroblast invasion to block fibrogenesis

Provided are methods of treating tissue fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a hyaluron synthase (HAS) or CD44. Further provided are methods of inhibiting myofibroblast invasion, or of reducing matrix deposition in the lung, the methods comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a HAS or CD44. Further provided are methods of determining the progression of pulmonary fibrosis, the methods comprising determining the level of matrix metalloproteinase expression in a cell, and comparing the level of expression to that of a control cell, wherein an increased level of expression relative to the control cell indicates progression of the disease.

Duke File (IDF) Number

T-003676

Inventor(s)

  • Noble, Paul
  • Jiang, Dianhua

For more information please contact

College

School of Medicine (SOM)

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