Transcriptional signature of Aspergillus infection

Value Proposition

Aspergillus is a type of fungal mold than can cause infections called aspergillosis. Infections usually results in affecting the respiratory system. While most strains of aspergillus are harmless and only cause minor allergic reactions, some individuals are at a higher risk of serious illness due to weakened immune systems. Oncology and organ recipient are specifically at higher risk of developing invasive aspergillosis that can spread from the lungs into the blood stream. However, there are only a few tools to diagnose aspergillus infections. These methods include inconclusive chest imaging and invasive tissue collection for analysis. There is an unmet need to develop new diagnostic tools for invasive aspergillosis.


Here, Steinbrink and colleagues identified a novel transcriptomic signature of aspergillus infection using next generation sequencing. This signature has the potential to be used as a diagnostic tool for detection of invasive aspergillosis and has been demonstrated in mouse studies.


  • New diagnostic method for aspergillus infections that is specific and non-invasive
  • Can diagnose early infections

Duke File (IDF) Number



  • Steinbrink, Julie
  • Betancourt-Quiroz, Marisol
  • Corcoran, David
  • McClain, Micah
  • Modliszewski, Jennifer
  • Zaas, Aimee

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School of Medicine (SOM)