Use of bacterial voltage gated ion channels for human therapies
This invention overcomes inability to use voltage-gated mammalian sodium and calcium channels for gain-of-function gene therapies in humans. Voltage-gated mammalian sodium and calcium channels have large size which precludes their packaging in standard viral vectors used for stable gene therapy applications in humans. Certain classes and engineered mutations of prokaryotic (bacterial) sodium channels in this invention can be packaged in therapeutic vectors and used to manipulate human tissues whose function relies of sodium and calcium channels (e.g. heart, brain, skeletal muscle, pancreas, etc).